Immune Evasion of SARS-CoV-2 Variants of Concern is Driven by Low Affinity to Neutralizing Antibodies
by Matheus Ferraz et al.Abstract SARS-CoV-2 VOCs immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOC is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. P.3 variant is a putative VOC.
14th May 2021 •
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